Overview of Services
Chemical analyses form the foundation for the reliable characterization and evaluation of substances, materials, and samples. At Seibersdorf Laboratories, we analyze a broad spectrum of sample types, including environmental and geological samples, chemical and active substances, and biological materials.
Using advanced analytical techniques combined with extensive expertise, we support industry, regulatory bodies, and research institutions in addressing questions related to quality, safety, composition, and potential contamination.
Environmental, Geochemical and Chemical Analysis
Accredited testing laboratory in accordance with EN ISO/IEC 17025 - Accurate chemical analysis for over 30 years
As a certified test laboratory in accordance with EN ISO/IEC 17025 and EN ISO 9001, we offer you the highest level of analytical expertise for environmentally relevant and geological samples. For more than three decades, we have stood for reliable results, modern laboratory equipment and a highly qualified team - your partner for complex analytical challenges.
Our Strengths
Doping Control Analysis
WADA-accredited doping control laboratory
As the only WADA-accredited doping control laboratory in Austria - and one of approximately 30 worldwide - we provide the highest level of analytical expertise to national anti-doping agencies (NADAs) as well as national and international sports organizations.
Established in 1999 through a joint initiative of the Federal Ministry of Public Services and Sport, the Austrian Anti-Doping Committee, and the Austrian Olympic Committee, we are a trusted partner in ensuring fair and clean competition.
Research & Innovation: International Standards from Seibersdorf
As a WADA laboratory, we are committed to research - with a focus on the detection of hard-to-detect doping agents, in particular:
- Recombinant erythropoietin (EPO)
- Testosterone doping
Analytical methods developed at Seibersdorf Laboratories are recognized as international standards and are widely implemented by WADA-accredited laboratories worldwide. Our research activities are supported by national and international funding programs, including the Federal Ministry of Arts, Culture, Public Service and Sport.
Forensics
Legally robust results accompanied by sound scientific interpretation
Since 2005, the Chemical Analytics division has provided forensic analyses based on state-of-the-art technology and extensive expertise. Led by Prof. Dr. Günter Gmeiner, a renown court-appointed expert in general applied and analytical chemistry with a focus on forensic chemistry, forensic toxicology, and doping analysis, our team delivers legally robust results accompanied by sound scientific interpretation.
Our Range of Services: Forensics
1. Blood alcohol and drug screening in road traffic
On behalf of the relevant authorities, we conduct blood alcohol analyses and drug screenings (blood and urine) following traffic controls. Our comprehensive screening covers several hundred substances, including all relevant compounds that may impair driving ability.
Analyses are performed in accordance with the EN ISO/IEC 17025 quality standard, ensuring reliable and legally defensible results.
2. Forensic analyses for courts and autopsies
We support courts and forensic pathologists in determining causes through comprehensive drug analyses. Our targeted analyses enable the identification of approximately 450 forensically relevant substances. In addition, our subsequent “general unknown” screening allows for the detection of up to 20,000 substances by matching mass spectra against established databases.
Proteomics
Proteomics & Analytical Biochemistry - Modern solutions for research and pharmaceuticals
Our research laboratory offers you the full range of cutting-edge proteomics methods - from consulting to project management. With cutting-edge technology and established working techniques, we support you in biomarker research, pharmaceutical development and biosimilarity studies.
Key Technologies & Instrumental Equipment
Our Established Working Techniques for Proteomics Projects
Your Advantage
Quality Standards
Quality management systems create the basis for reliable processes, verifiable results and compliance with regulatory requirements. Seibersdorf Laboratories supports organizations in setting up, further developing and adapting suitable QM structures to international standards.
Our expertise ranges from the introduction and evaluation of quality management systems to practical support for audits, accreditations and the continuous improvement of processes.
Laboratory Equipment
The quality of chemical analyses is largely determined by the measurement technologies employed. Seibersdorf Laboratories is equipped with modern, versatile instrumentation that enables the reliable analysis of a wide range of sample types.
Depending on the specific analytical requirements, specialized methods and measurement systems are applied to ensure precise determination of composition, trace components, and potential contaminants.
The following analysis techniques are available:
- LC/HRMS
(liquid chromatography with high-resolution mass spectrometric detection) - LC/MS/MS
(liquid chromatography with tandem mass spectrometric detection) - HPLC with DAD
(high-performance liquid chromatography with diode array detector) - GC/MS
(gas chromatography with mass spectrometric detection) - GC/MS/MS
(gas chromatography with tandem mass spectrometric detection) - GC/C/IRMS
(gas chromatography with combustion isotopic ratio mass spectrometry) - HS/GC/FID
(headspace gas chromatography with flame ionization detector)
- Gel electrophoresis with various types of detection
- ICP/MS
(inductively coupled plasma/mass spectrometric detection) - ICP/AES
(inductively coupled plasma/atomic emission spectroscopy) - Cold steam AAS
(atomic absorption spectroscopy, for mercury) - IC
(ion chromatography with conductivity detector) - AOX/POX/EOX analyzer
- TOC analyzer
- photometer
- Potentiometric methods
List of Publications
| Year | Publication |
|---|---|
| 2025 | Reichel C, Filip T, Gmeiner G, Thevis M. Gel electrophoretic detection of black market ACE-031. Drug Test Anal. 2025; 17 (10) :1934-1946. |
| Reichel C, Gmeiner G, Thevis M. Cost Minimized Immunoaffinity Purification of EPO and Its Analogs in Doping Control—A Step-by-Step Protocol for Human Urine and Blood. Drug test anal. 2025; 17 (9) :1545-1559. | |
| 2023 | Reichel C, Erceg D, Lorenc B, Scheiblhofer V, Farmer L, Zanitzer K, Geisendorfer T, Gmeiner G, Thevis M. Data from a microdosed recombinant human erythropoietin administration study applying the new biotinylated clone AE7A5 antibody and a further optimized sarcosyl polyacrylamide gel electrophoresis protocol. Drug test anal. 2023; 15 (2) :163-172. |
| 2022 | Reichel C, Gmeiner G, Thevis M. Electrophoretic detection of black market myostatin propeptides. Drug test anal. 2022; 14 (11-12) :1812-1824. |
| 2020 | Walpurgis K, Weigand T, Knoop A, Thomas A, Reichel C, Dellanna F, Thevis M. Detection of follistatin-based inhibitors of the TGF-β signaling pathways in serum/plasma by means of LC-HRMS/MS and western blotting. Drug test anal. 2020; 12 (11-12) :1636-1648. |
| 2019 | Reichel C, Gmeiner G, Thevis M. Detection of black market follistatin 344. Drug test anal. 2019; 11 (11-12) :1675-1697. |
| Reichel C, Gmeiner G, Reihlen P, Thevis M, Schänzer W. SARCOSYL-PAGE: Optimized Protocols for the Separation and Immunological Detection of PEGylated Proteins. Methods Mol Biol. 2019; 1855:131-149. | |
| 2018 | Walpurgis K, Reichel C, Thomas A, Thevis M. Combined detection of the ActRII-FC fusion proteins sotatercept (Actriia-FC) and luspatercept (modified ActRIIB-FC) in serum by means of immunoaffinity purification, tryptic digestion, and LC-MS/MS. Drug Test Anal. 2018; 10 (11-12) :1714-1721. |
| Reichel C, Gmeiner G, Walpurgis K, Thevis M. Updated protocols for the detection of sotatercept and luspatercept in human serum. Drug test anal. 2018; 10 (11-12) :1708-1713. | |
| Metrustry SJ, Karhunen V, Edwards MH, Menni C, Geisendorfer T, Huber A, Reichel C, Dennison EM, Cooper C, Spector T, Jarvelin MR, Valdes AM. Metabolomic signatures of low birthweight: Pathways to insulin resistance and oxidative stress. PLoS One 2018; 13 (3) :e0194316. | |
| Reichel C, Farmer L, Gmeiner G, Walpurgis K, Thevis M. Detection of Sotatercept (ACE-011) in human serum by SAR-PAGE and Western Single Blotting. Drug test anal. 2018; 10 (6) :927-937. | |
| 2017 | Reichel C, Gmeiner G, Thevis M. Antibody-based strategies for the detection of luspatercept (ACE-536) in human serum. Drug test anal. 2017; 9 (11-12) :1721-1730. |
| 2016 | Walpurgis K, Thomas A, Vogel M, Reichel C, Geyer H, Schänzer W, Thevis M. Testing for the erythropoiesis-stimulating agent Sotatercept/ACE-011 (Actriia-FC) in serum by means of Western blotting and LC-HRMS. Drug test anal. 2016; 8 (11-12) :1152-1161. |
| Reichel C, Benetka W, Lorenc B, Thevis M. Evaluation of AMGEN clone 9G8A anti-EPO antibody for application in doping control. Drug test anal. 2016; 8 (11-12) :1131-1137. | |
| 2015 | Row P, Blobel M, Kempkes R, Reichel C, Völker Schänzer E, Majer B, Schänzer W. Optimizing SAR-PAGE. Drug test anal. 2015; 7 (11-12) :1014-6. |
| 2015 | Menni C, Graham D, Kastenmüller G, Alharbi NH, Alsanosi SM, McBride M, Mangino M, Titcombe P, Shin SY, Psatha M, Geisendorfer T, Huber A, Peters A, Wang-Sattler R, Xu T, Brosnan MJ, Trimmer J, Reichel C, Mohney RP, Soranzo N, Edwards MH, Cooper C, Church AC, Suhre K, Gieger C, Dominiczak AF, Spector TD, Padmanabhan S, Valdes AM. Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension. 2015; 66 (2) :422-9. |
| Reichl P, Dengler M, van Zijl F, Huber H, Führlinger G, Reichel C, Sieghart W, Peck-Radosavljevic M, Grubinger M, Mikulits W. Axl activates autocrine transforming growth factor-β signaling in hepatocellular carcinoma. Hepatology. 2015; 61 (3) :930-41. | |
| 2014 | Vogel M, Blobel M, Thomas A, Walpurgis K, Schänzer W, Reichel C, Thevis M. Isolation, enrichment, and analysis of erythropoietins in anti-doping analysis by receptor-coated magnetic beads and liquid chromatography-mass spectrometry. Anal Chem. 2014; 86 (24) :12014-21. |
| Dvorak J, Baume N, Botré F, Broseus J, Budgett R, Frey WO, Geyer H, Harcourt PR, Ho D, Howman D, Isola V, Lundby C, Marclay F, Peytavin A, Pipe A, Pitsiladis YP, Reichel C, Robinson N, Rodchenkov G, Saugy M, Sayegh S, Segura J, Evis M, Vernec A, Viret M, Vouillamoz M, Zorzoli M. Time for Change: A Roadmap to Guide the Implementation of the World Anti-Doping Code 2015. Br J Sports Med. 2014; 48 (10) :801-6. | |
| Golec M, Reichel C, Lemieszek M, Buczkowski J, Mackiewicz B, Skórska C, Dutkiewicz J, Gora A, Ziesche R, Milanowski J. Cathelicidin LL-37 in bronchoalveolar lavage and epithelial lining fluids from healthy individuals and sarcoidosis patients. J Biol Regul Homeost Agents. 2014 ,28 (1) :73-9. | |
| Reichel C. Detection of peptidic erythropoiesis-stimulating agents in sport. Br J Sports Med. 2014; 48 (10) :842-7. | |
| 2013 | Reichel C. Differences in sialic acid O-acetylation between human urinary and recombinant erythropoietins: a possible mass spectrometric marker for doping control. Drug testing. Analysis 2013, 5, 877-889. |
| Reichel C, Thevis M. Gel electrophoretic methods for the analysis of biosimilar pharmaceuticals using the example of recombinant erythropoietin. Bioanalysis 2013, 5, 587-602. | |
| Vasiloiua M, Rainera D, Gärtner P, Reichel C, Schröder C, Bicaa K. Basic chiral ionic liquids: A novel strategy for acid-free organocatalysis. Catalysis Today 2013, 200, 80-86. | |
| Vasiloiua M, Rainera D, Gärtner P, Reichel C, Schröder C, Bicaa K. Basic chiral ionic liquids: A novel strategy for acid-free organocatalysis. Catalysis Today 2013, 200, 80-86. | |
| 2012 | Golec M, Reichel C, Lemieszek M, Mackiewicz B, Buczkowski J, Sitkowska J, Dutkiewicz J, Milanowski J, Ziesche R. Cathelicidin LL-37 in bronchoalveolar lavage and epithelial lining fluids from COPD patients and healthy individuals. J Biol Regul Homeost Agents 2012, 26, 617-625. |
| Reichel C. Sports Drug Testing for Erythropoiesis-Stimulating Agents and Autologous Blood Transfusion, Drug Test. Analysis 2012, 4, 803—804. | |
| Reichel C. Mass spectrometric analysis of EPO IEF-PAGE interfering substances in nitrile examination gloves, drug test. Analysis 2012, 4, 761—774. | |
| Reichel C. Application of high-throughput IEF-PAGE for EPO doping testing, drug test. Analysis 2012, 4, 728—732. | |
| Leuenberger N, Reichel C, Lasne F. Detection of erythropoiesis-stimulating agents in human anti-doping control: past, present and future, Bioanalysis 2012, 13, 1565-1575. | |
| Reichel C, Thevis M. Detection of Epo-FC fusion protein in human blood: screening and confirmation protocols for sports drug testing, drug test. Analysis 2012, 4, 818—829. | |
| Reichel C. SARCOSYL-PAGE: A New Electrophoretic Method for the Separation and Immunological Detection of PEGylated Proteins, Methods Mol Biol. 2012, 869, 65-79. | |
| 2011 | Reichel C. The Overlooked Difference between Human Endogenous and Recombinant Erythropoietins and its Implication for Sports Drug Testing and Pharmaceutical Drug Design, Drug Test. Analysis 2011; 3, 883-891. |
| Reichel C. Omics-Strategies and Methods in the Fight Against Doping, Forensic Sci Int. 2011; 213, 20-34. | |
| Reichel C. Recent developments in doping testing for erythropoietin, Anal Bioanal Chem. 2011; 401, 463-481. | |
| 2010 | Reichel C. Practicing IEF-PAGE of EPO: The Impact of Detergents and Sample Application Methods on Analytical Performance in Doping Control, Drug Test. Analysis 2010; 2, 603-619. |
| Reichel C, Benetka E, Geisendorfer T, Scheiblhofer V, puller F. The interference of heparin on IEF-PAGE of erythropoietins, drug test. Analysis 2010; 2, 568-575. | |
| Gmeiner G, Reichel C, Kulovics R, Scheiblhofer V. Defending Dynepo Detection, Drug Test. Analysis 2010; 2, 526-532. | |
| Bilalic S, Veitinger M, Ahrer KH, Gruber V, Zellner M, Brostjan C, Bartel G, Cejka D, Reichel C, Jordan V, Burghuber C, Mühlbacher F, Böhmig GA, Oehler R: Identification of non-HLA antigens targeted by alloreactive antibodies in patients undergoing chronic hemodialysis, J Proteome Res. 2010; 9, 1041-1049. | |
| Reichel C, Gmeiner G. Erythropoietin and analogs, Handb Exp Pharmacol. 2010; 195, 251-94. | |
| 2009 | Golec M., Reichel C., Mackiewicz B., Skórska C., Curzytek K., Lemieszek M., Dutkiewicz J., Gora A., Ziesche R., Bołtuć J., Sodolska K., Milanowski J., Śpiewak R.: Cathelicidin LL-37, granzymes, TGF-β1 and cytokines levels in induced sputum from farmers with and without COPD, Ann Agric Environ Med 2009; 16, 289—297. |
| Reichel C, puller F, Geisendorfer T. SARCOSYL-PAGE: a new method for the detection of MIRCERA and EPO doping in blood, drug test. Analysis 2009; 1, 494—504. | |
| Marchetti-Deschmann M, Kemptner J, Reichel C, Allmaier G. Comparing standard and microwave-assisted staining protocols for SDS-PAGE of glycoproteins followed by subsequent PMF with MALDI MS, J Proteomics 2009; 72, 628-639. | |
| Reichel C, Kulovics R, Jordan V, Watzinger M, Geisendorfer T. SDS-PAGE of Recombinant and Endogenous Erythropoietins: Benefits and Limitations of the Method for Application in Doping Control, Drug Test. Analysis 2009; 1, 43-50. | |
| 2008 | Reichel C. Identification of zinc-alpha-2-glycoprotein binding to clone AE7A5 anti-human Epo antibody by means of nano-HPLC and high-resolution high-mass accuracy ESI-MS/MS, J Mass Spectrom. 2008; 43, 916-923. |
| Gärtner P, Hofbauer K, Reichel C, Geisendorfer T, Gmeiner G. Synthesis and identification of hydroxylated metabolites of the anti-estrogenic agent cyclofenil, J Mass Spectrom. 2008; 43, 958-964. | |
| 2007 | Bica K, Gmeiner G, Reichel C, Lendl B, Gärtner P. Microwave-Assisted Synthesis of Camphor-Derived Chiral Imidazolium Ionic Liquids and Their Application in Diastereoselective Diels-Alder Reaction, Synthesis 2007; 9, 1333-1338. |
| 2005 | Stübiger G, Marchetti M, Nagano M, Grimm R, Gmeiner G, Reichel C, Allmaier G. Characterization of N- and O-glycopeptides of recombinant human erythropoietins as potential biomarkers for doping analysis by means of micro-scale sample purification combined with MALDI TOF and QIT/RTOF mass spectrometry, J Sep Sci. 2005; 28, 1764-1778. |
| Nagano M, Stübiger G, Marchetti M, Gmeiner G, Allmaier G, Reichel C. Detection of isoforms of recombinant human erythropoietin by various plant lectins after isoelectric focusing, Electrophoresis 2005; 26, 1633-1645. | |
| Stübiger G, Marchetti M, Nagano M, Reichel C, Gmeiner G, Allmaier G. Characterization of Intact Recombinant Human Erythropoietins Applied in Doping by Means of Planar Gel Electrophoretic Techniques and Matrix-Assisted Laser Desorption/Ionization Linear Time-of-Flight Mass Spectrometry, Rapid Commun Mass Spectrometry. 2005; 19, 728-42. | |
| Bajla I, Hollander I, Minichmayr M, Gmeiner G, Reichel C. GasEPO — a software solution for quantitative analysis of digital images in Epo doping control, Comput Methods Programs Biomed. 2005; 80, 246-270. | |
| Bajla I, Hollander I, Gmeiner G, Reichel C. Quantitative analysis of images in erythropoietin doping control, Med Biol Eng Comput. 2005; 43, 403-409. |
